The present work describes the optimization and validation of a highly selective and\nsensitive analytical method using solid phase extraction and liquid chromatography tandem mass\nspectrometry (SPE LC-MS/MS) for the determination of some frequently prescribed pharmaceuticals\nin urban wastewater received and treated by Sharjah sewage treatment plant (STP). The extraction\nefficiency of different SPE cartridges was tested and the simultaneous extraction of pharmaceuticals\nwas successfully accomplished using hydrophilic-lipophilic-balanced reversed phaseWaters® Oasis\nHLB cartridge (200 mg/ 6 mL) at pH 3. The analytes were separated on an Aquity BEH C18 column.............
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